full break down of population level effects

core demographics table

control PD prodromal p
(N=161) (N=505) (N=395)
subjectAge_BL 60.2 ± 11.6 62.3 ± 9.6 62.7 ± 7.1 0.012
subjectSex < 0.001
    F 59 (36.6%) 198 (39.2%) 215 (54.4%)
    M 102 (63.4%) 307 (60.8%) 180 (45.6%)
mds_updrs_part_i_summary_score 2.9 ± 3.1 6.6 ± 4.9 5.6 ± 4.5 < 0.001
mds_updrs_part_ii_summary_score 0.4 ± 1.0 6.4 ± 4.8 1.3 ± 2.5 < 0.001
mds_updrs_part_iii_summary_score 0.9 ± 1.9 20.8 ± 9.1 3.0 ± 4.2 < 0.001
code_upd2hy_hoehn_and_yahr_stage < 0.001
    0 160 (99.4%) 110 (21.8%) 378 (95.7%)
    1 1 ( 0.6%) 163 (32.3%) 13 ( 3.3%)
    2 0 ( 0.0%) 227 (45.0%) 4 ( 1.0%)
    3 0 ( 0.0%) 5 ( 1.0%) 0 ( 0.0%)
geneticMutation < 0.001
    Absent 161 (100.0%) 349 (69.1%) 62 (15.7%)
    GBA 0 ( 0.0%) 44 ( 8.7%) 166 (42.0%)
    LRRK2 0 ( 0.0%) 112 (22.2%) 167 (42.3%)
has24 < 0.001
    FALSE 155 (96.3%) 398 (78.8%) 372 (94.2%)
    TRUE 6 ( 3.7%) 107 (21.2%) 23 ( 5.8%)
has48 < 0.001
    FALSE 158 (98.1%) 469 (92.9%) 324 (82.0%)
    TRUE 3 ( 1.9%) 36 ( 7.1%) 71 (18.0%)

sex, genetics, model, DX

reproducibility: ICC

reproducibility: Mean absolute difference

reproducibility: Correlation vs Model-adjusted correlation

raw corr

mod-adj corr

discrimination: control vs prodromal vs PD

best model: confusion matrix - cross-pred - raw accuracy - 3-class

best model: confusion matrix - cross-pred - raw accuracy - 2-class

summarize overall improvement by class with measurement type / dx regression

effects of mfg.model

longitudinal scanner effect

longitudinal connectivity study

longitudinal roi study

roi study results

grepper type 1 ippo temporal [1] “fa_LRAVG_parahippocampal” “md_LRAVG_parahippocampal”
[3] “fa.cingulum_.hippocampus..Asym” “md.cingulum_.hippocampus..Asym” [5] “fa_Asym_parahippocampal” “md_Asym_parahippocampal”
grepper type 2 rhin temporal [1] “entorhinal_to_LRAVG_insula” ”fa_LRAVG_entorhinal”
[3] ”md_LRAVG_entorhinal” ”fa_Asym_entorhinal”
[5] ”md_Asym_entorhinal”
grepper type 3 empor temporal [1] ”inferior_temporal_to_LRAVG_insula”
[2] ”superior_temporal_to_LRAVG_insula”
[3] ”transverse_temporal_to_LRAVG_insula” [4] ”fa_LRAVG_inferior_temporal”
[5] ”fa_LRAVG_middle_temporal”
[6] ”fa_LRAVG_superior_temporal”
[7] ”fa_LRAVG_transverse_temporal”
[8] ”md_LRAVG_inferior_temporal”
[9] ”md_LRAVG_middle_temporal”
[10] ”md_LRAVG_superior_temporal”
[11] ”md_LRAVG_transverse_temporal”
[12] ”fa_Asym_inferior_temporal”
[13] ”fa_Asym_middle_temporal”
[14] ”fa_Asym_superior_temporal”
[15] ”fa_Asym_transverse_temporal”
[16] ”md_Asym_inferior_temporal”
[17] ”md_Asym_middle_temporal”
[18] ”md_Asym_superior_temporal”
[19] ”md_Asym_transverse_temporal”
grepper type 4 usiform temporal [1] ”fusiform_to_LRAVG_insula” ”fa_LRAVG_fusiform”
[3] ”md_LRAVG_fusiform” ”fa_Asym_fusiform”
[5] ”md_Asym_fusiform”
grepper type 5 frontal frontal [1] ”caudal_middle_frontal_to_LRAVG_insula” [2] ”lateral_orbitofrontal_to_LRAVG_insula” [3] ”medial_orbitofrontal_to_LRAVG_insula”
[4] ”rostral_middle_frontal_to_LRAVG_insula” [5] ”fa_LRAVG_caudal_middle_frontal”
[6] ”fa_LRAVG_lateral_orbitofrontal”
[7] ”fa_LRAVG_medial_orbitofrontal”
[8] ”fa_LRAVG_rostral_middle_frontal”
[9] ”fa_LRAVG_superior_frontal”
[10] ”md_LRAVG_caudal_middle_frontal”
[11] ”md_LRAVG_lateral_orbitofrontal”
[12] ”md_LRAVG_medial_orbitofrontal”
[13] ”md_LRAVG_rostral_middle_frontal”
[14] ”md_LRAVG_superior_frontal”
[15] ”fa_Asym_caudal_middle_frontal”
[16] ”fa_Asym_lateral_orbitofrontal”
[17] ”fa_Asym_medial_orbitofrontal”
[18] ”fa_Asym_rostral_middle_frontal”
[19] ”fa_Asym_superior_frontal”
[20] ”md_Asym_caudal_middle_frontal”
[21] ”md_Asym_lateral_orbitofrontal”
[22] ”md_Asym_medial_orbitofrontal”
[23] ”md_Asym_rostral_middle_frontal”
[24] ”md_Asym_superior_frontal”
grepper type 6 cingulate mid [1] ”isthmus_cingulate_to_LRAVG_insula”
[2] ”rostral_anterior_cingulate_to_LRAVG_insula” [3] ”md.cingulum.cingulate_gyrus..LRAVG”
[4] ”fa_LRAVG_caudal_anterior_cingulate”
[5] ”fa_LRAVG_isthmus_cingulate”
[6] ”fa_LRAVG_posterior_cingulate”
[7] ”fa_LRAVG_rostral_anterior_cingulate”
[8] ”md_LRAVG_caudal_anterior_cingulate”
[9] ”md_LRAVG_isthmus_cingulate”
[10] ”md_LRAVG_posterior_cingulate”
[11] ”md_LRAVG_rostral_anterior_cingulate”
[12] ”fa.cingulum.cingulate_gyrus..Asym”
[13] ”md.cingulum.cingulate_gyrus..Asym”
[14] ”fa_Asym_caudal_anterior_cingulate”
[15] ”fa_Asym_isthmus_cingulate”
[16] ”fa_Asym_posterior_cingulate”
[17] ”fa_Asym_rostral_anterior_cingulate”
[18] ”md_Asym_caudal_anterior_cingulate”
[19] ”md_Asym_isthmus_cingulate”
[20] ”md_Asym_posterior_cingulate”
[21] ”md_Asym_rostral_anterior_cingulate”
grepper type 7 uneus mid [1] ”cuneus_to_LRAVG_insula” ”precuneus_to_LRAVG_insula” [3] ”fa_LRAVG_cuneus” ”fa_LRAVG_precuneus”
[5] ”md_LRAVG_cuneus” ”md_LRAVG_precuneus”
[7] ”fa_Asym_cuneus” ”fa_Asym_precuneus”
[9] ”md_Asym_cuneus” ”md_Asym_precuneus”
grepper type 8 central central [1] ”paracentral_to_LRAVG_insula” ”postcentral_to_LRAVG_insula” [3] ”precentral_to_LRAVG_insula” ”fa_LRAVG_paracentral”
[5] ”fa_LRAVG_postcentral” ”fa_LRAVG_precentral”
[7] ”md_LRAVG_paracentral” ”md_LRAVG_postcentral”
[9] ”md_LRAVG_precentral” ”fa_Asym_paracentral”
[11] ”fa_Asym_postcentral” ”fa_Asym_precentral”
[13] ”md_Asym_paracentral” ”md_Asym_postcentral”
[15] ”md_Asym_precentral”
grepper type 9 jhu jhu character(0) grepper type 10 deep deep [1] ”fa_deep_bn_gp_gpe_LRAVG” ”fa_deep_bn_gp_gpi_LRAVG”
[3] ”fa_deep_bn_str_ca_LRAVG” ”fa_deep_bn_str_pu_LRAVG”
[5] ”fa_deep_mtg_rn_LRAVG” ”fa_deep_mtg_sn_snc_LRAVG”
[7] ”fa_deep_mtg_sn_snr_LRAVG” ”fa_deep_referenceregion_LRAVG” [9] ”md_deep_bn_gp_gpe_LRAVG” ”md_deep_bn_gp_gpi_LRAVG”
[11] ”md_deep_bn_str_ca_LRAVG” ”md_deep_bn_str_pu_LRAVG”
[13] ”md_deep_mtg_rn_LRAVG” ”md_deep_mtg_sn_snc_LRAVG”
[15] ”md_deep_mtg_sn_snr_LRAVG” ”md_deep_referenceregion_LRAVG” [17] ”fa_deep_bn_gp_gpe_Asym” ”fa_deep_bn_gp_gpi_Asym”
[19] ”fa_deep_bn_str_ca_Asym” ”fa_deep_bn_str_pu_Asym”
[21] ”fa_deep_mtg_rn_Asym” ”fa_deep_mtg_sn_snc_Asym”
[23] ”fa_deep_mtg_sn_snr_Asym” ”fa_deep_referenceregion_Asym” [25] ”md_deep_bn_gp_gpe_Asym” ”md_deep_bn_gp_gpi_Asym”
[27] ”md_deep_bn_str_ca_Asym” ”md_deep_bn_str_pu_Asym”
[29] ”md_deep_mtg_rn_Asym” ”md_deep_mtg_sn_snc_Asym”
[31] ”md_deep_mtg_sn_snr_Asym” ”md_deep_referenceregion_Asym” grepper type 11 ch13 BF [1] ”fa_ch13_LRAVG” ”md_ch13_LRAVG” ”fa_ch13_Asym” ”md_ch13_Asym” grepper type 12 nbm BF [1] ”fa_nbm_LRAVG_ant” ”fa_nbm_LRAVG_mid” ”fa_nbm_LRAVG_pos” ”md_nbm_LRAVG_ant” [5] ”md_nbm_LRAVG_mid” ”md_nbm_LRAVG_pos” ”fa_nbm_Asym_ant” ”fa_nbm_Asym_mid” [9] ”fa_nbm_Asym_pos” ”md_nbm_Asym_ant” ”md_nbm_Asym_mid” ”md_nbm_Asym_pos” grepper type 13 fa[.] WM [1] ”fa.anterior_corona_radiata.LRAVG”
[2] ”fa.posterior_limb_of_internal_capsule.LRAVG”
[3] ”fa.posterior_thalamic_radiation.include_optic_radiation..LRAVG”
[4] ”fa.tapetum.LRAVG”
[5] ”fa.anterior_corona_radiata.Asym”
[6] ”fa.anterior_limb_of_internal_capsule.Asym”
[7] ”fa.cerebral_peduncle.Asym”
[8] ”fa.cingulum.cingulate_gyrus..Asym”
[9] ”fa.cingulum.hippocampus..Asym”
[10] ”fa.corticospinal_tract.Asym”
[11] ”fa.external_capsule.Asym”
[12] ”fa.fornix.cres..stria_terminalis.can_not_be_resolved_with_current_resolution..Asym”
[13] ”fa.inferior_cerebellar_peduncle.Asym”
[14] ”fa.inferior_fronto.occipital_fasciculus.Asym”
[15] ”fa.medial_lemniscus.Asym”
[16] ”fa.posterior_corona_radiata.Asym”
[17] ”fa.posterior_limb_of_internal_capsule.Asym”
[18] ”fa.posterior_thalamic_radiation.include_optic_radiation..Asym”
[19] ”fa.retrolenticular_part_of_internal_capsule.Asym”
[20] ”fa.sagittal_stratum.include_inferior_longitidinal_fasciculus_and_inferior_fronto.occipital_fasciculus..Asym” [21] ”fa.superior_cerebellar_peduncle.Asym”
[22] ”fa.superior_corona_radiata.Asym”
[23] ”fa.superior_fronto.occipital_fasciculus.could_be_a_part_of_anterior_internal_capsule..Asym”
[24] ”fa.superior_longitudinal_fasciculus.Asym”
[25] ”fa.tapetum.Asym”
[26] ”fa.uncinate_fasciculus.Asym”
grepper type 14 md[.] WM [1] ”md.cingulum.cingulate_gyrus..LRAVG”
[2] ”md.external_capsule.LRAVG”
[3] ”md.inferior_cerebellar_peduncle.LRAVG”
[4] ”md.inferior_fronto.occipital_fasciculus.LRAVG”
[5] ”md.medial_lemniscus.LRAVG”
[6] ”md.posterior_corona_radiata.LRAVG”
[7] ”md.posterior_limb_of_internal_capsule.LRAVG”
[8] ”md.posterior_thalamic_radiation.include_optic_radiation..LRAVG”
[9] ”md.retrolenticular_part_of_internal_capsule.LRAVG”
[10] ”md.sagittal_stratum.include_inferior_longitidinal_fasciculus_and_inferior_fronto.occipital_fasciculus..LRAVG” [11] ”md.superior_cerebellar_peduncle.LRAVG”
[12] ”md.superior_corona_radiata.LRAVG”
[13] ”md.superior_fronto.occipital_fasciculus.could_be_a_part_of_anterior_internal_capsule..LRAVG”
[14] ”md.superior_longitudinal_fasciculus.LRAVG”
[15] ”md.tapetum.LRAVG”
[16] ”md.uncinate_fasciculus.LRAVG”
[17] ”md.anterior_corona_radiata.Asym”
[18] ”md.anterior_limb_of_internal_capsule.Asym”
[19] ”md.cerebral_peduncle.Asym”
[20] ”md.cingulum.cingulate_gyrus..Asym”
[21] “md.cingulum_.hippocampus..Asym”
[22] “md.corticospinal_tract.Asym”
[23] “md.external_capsule.Asym”
[24] “md.fornix_.cres..stria_terminalis_.can_not_be_resolved_with_current_resolution..Asym”
[25] “md.inferior_cerebellar_peduncle.Asym”
[26] “md.inferior_fronto.occipital_fasciculus.Asym”
[27] “md.medial_lemniscus.Asym”
[28] “md.posterior_corona_radiata.Asym”
[29] “md.posterior_limb_of_internal_capsule.Asym”
[30] “md.posterior_thalamic_radiation_.include_optic_radiation..Asym”
[31] “md.retrolenticular_part_of_internal_capsule.Asym”
[32] “md.sagittal_stratum_.include_inferior_longitidinal_fasciculus_and_inferior_fronto.occipital_fasciculus..Asym” [33] “md.superior_cerebellar_peduncle.Asym”
[34] “md.superior_corona_radiata.Asym”
[35] “md.superior_fronto.occipital_fasciculus_.could_be_a_part_of_anterior_internal_capsule..Asym”
[36] “md.superior_longitudinal_fasciculus.Asym”
[37] “md.tapetum.Asym”
[38] “md.uncinate_fasciculus.Asym”
grepper type 15 parietal parietal [1] “_inferior_parietal_to_LRAVG_insula” “_superior_parietal_to_LRAVG_insula” [3] “fa_LRAVG_inferior_parietal” “fa_LRAVG_superior_parietal”
[5] “md_LRAVG_inferior_parietal” “md_LRAVG_superior_parietal”
[7] “fa_Asym_inferior_parietal” “fa_Asym_superior_parietal”
[9] “md_Asym_inferior_parietal” “md_Asym_superior_parietal”
grepper type 16 insula mid [1] “_caudal_middle_frontal_to_LRAVG_insula”
[2] “_cuneus_to_LRAVG_insula”
[3] “_entorhinal_to_LRAVG_insula”
[4] “_fusiform_to_LRAVG_insula”
[5] “_inferior_parietal_to_LRAVG_insula”
[6] “_inferior_temporal_to_LRAVG_insula”
[7] “_isthmus_cingulate_to_LRAVG_insula”
[8] “_lateral_occipital_to_LRAVG_insula”
[9] “_lateral_orbitofrontal_to_LRAVG_insula”
[10] “_lingual_to_LRAVG_insula”
[11] “_medial_orbitofrontal_to_LRAVG_insula”
[12] “_paracentral_to_LRAVG_insula”
[13] “_pars_opercularis_to_LRAVG_insula”
[14] “_pars_orbitalis_to_LRAVG_insula”
[15] “_pars_triangularis_to_LRAVG_insula”
[16] “_pericalcarine_to_LRAVG_insula”
[17] “_postcentral_to_LRAVG_insula”
[18] “_precentral_to_LRAVG_insula”
[19] “_precuneus_to_LRAVG_insula”
[20] “_rostral_anterior_cingulate_to_LRAVG_insula” [21] “rostral_middle_frontal_to_LRAVG_insula”
[22] ”superior_parietal_to_LRAVG_insula”
[23] ”superior_temporal_to_LRAVG_insula”
[24] ”transverse_temporal_to_LRAVG_insula”
[25] ”fa_LRAVG_insula”
[26] ”md_LRAVG_insula”
[27] ”fa_Asym_insula”
[28] ”md_Asym_insula”
grepper type 17 lingual occipital [1] ”lingual_to_LRAVG_insula” ”fa_LRAVG_lingual”
[3] ”md_LRAVG_lingual” ”fa_Asym_lingual”
[5] ”md_Asym_lingual”
grepper type 18 occipital occipital [1] ”lateral_occipital_to_LRAVG_insula”
[2] ”md.inferior_fronto.occipital_fasciculus.LRAVG”
[3] ”md.sagittal_stratum.include_inferior_longitidinal_fasciculus_and_inferior_fronto.occipital_fasciculus..LRAVG” [4] ”md.superior_fronto.occipital_fasciculus.could_be_a_part_of_anterior_internal_capsule..LRAVG”
[5] ”fa_LRAVG_lateral_occipital”
[6] ”md_LRAVG_lateral_occipital”
[7] ”fa.inferior_fronto.occipital_fasciculus.Asym”
[8] ”fa.sagittal_stratum.include_inferior_longitidinal_fasciculus_and_inferior_fronto.occipital_fasciculus..Asym” [9] ”fa.superior_fronto.occipital_fasciculus.could_be_a_part_of_anterior_internal_capsule..Asym”
[10] ”md.inferior_fronto.occipital_fasciculus.Asym”
[11] ”md.sagittal_stratum.include_inferior_longitidinal_fasciculus_and_inferior_fronto.occipital_fasciculus..Asym” [12] ”md.superior_fronto.occipital_fasciculus.could_be_a_part_of_anterior_internal_capsule..Asym”
[13] “fa_Asym_lateral_occipital”
[14] “md_Asym_lateral_occipital”
grepper type 19 pars_opercularis frontal [1] “_pars_opercularis_to_LRAVG_insula” “fa_LRAVG_pars_opercularis”
[3] “md_LRAVG_pars_opercularis” “fa_Asym_pars_opercularis”
[5] “md_Asym_pars_opercularis”
grepper type 20 pars_orbitalis frontal [1] “_pars_orbitalis_to_LRAVG_insula” “fa_LRAVG_pars_orbitalis”
[3] “md_LRAVG_pars_orbitalis” “fa_Asym_pars_orbitalis”
[5] “md_Asym_pars_orbitalis”
grepper type 21 pars_triangularis frontal [1] “_pars_triangularis_to_LRAVG_insula” “fa_LRAVG_pars_triangularis”
[3] “md_LRAVG_pars_triangularis” “fa_Asym_pars_triangularis”
[5] “md_Asym_pars_triangularis”
grepper type 22 pericalcarine occipital [1] “_pericalcarine_to_LRAVG_insula” “fa_LRAVG_pericalcarine”
[3] “md_LRAVG_pericalcarine” “fa_Asym_pericalcarine”
[5] “md_Asym_pericalcarine”
grepper type 23 supramarginal parietal [1] “fa_LRAVG_supramarginal” “md_LRAVG_supramarginal” “fa_Asym_supramarginal” [4] “md_Asym_supramarginal”

insula connectivity study results